The Game Census
S.E.M.I. – Side Effects May Include... cover art

S.E.M.I. – Side Effects May Include...

Two Horn Unicorn · 2026-01-23

Steam

ActionIndie

Modes: Single player, Multiplayer, Co-operative

Releases: Nov 20, 2025 (PC (Microsoft Windows))

S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects!

86%
positive of 112 reviews
Very Positive
steam rating
pending
deck/linux tier (ProtonDB)
$7.99
steam price (US)

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.(Storyline via IGDB)

Health check

Quiet
  • · 5 reviews in the last 8 weeks (~1/week).
  • · Review velocity down 72% vs the prior 8 weeks.
  • · Top 63% of 12,355 Action games in the census by review count.
Estimated sales: 2.2k–5.0k copies

Review-multiple estimate from 112 total reviews — how this is computed.

All-time low: $4.79 at Steam (2026-06-25)via IsThereAnyDeal

12-month high $7.99 · on sale 4 of 8 observed days (census price snapshots)

Review momentum

PositiveNegative
111120252026Week of 2025-11-20: 7 positiveWeek of 2025-11-20: 6 negativeWeek of 2025-11-27: 11 positiveWeek of 2025-12-04: 5 positiveWeek of 2025-12-04: 1 negativeWeek of 2025-12-18: 1 positiveWeek of 2026-01-01: 2 positiveWeek of 2026-01-15: 2 positiveWeek of 2026-01-22: 3 positiveWeek of 2026-01-22: 3 negativeWeek of 2026-01-29: 1 positiveWeek of 2026-02-05: 2 positiveWeek of 2026-03-12: 1 positiveWeek of 2026-03-19: 2 positiveWeek of 2026-07-16: 1 positive
Weekly review counts (Steam review histogram). Positive above the line, negative below.

Price history

$7.99$4.792025-11-202026-07-092025-11-20 — best price $6.792025-11-27 — best price $7.992026-01-23 — best price $5.592026-01-30 — best price $7.992026-03-19 — best price $5.592026-03-26 — best price $7.992026-06-25 — best price $4.792026-07-09 — best price $7.99
Lowest recorded price across tracked stores, per day (census snapshots).

Completion

9
achievements tracked
12.9%
earned "First Dose of Reality"
0.2%
median achievement earned by

Global achievement rates from Steam.

Details

WindowsFull controller supportSingle-playerMulti-playerCo-opOnline Co-opSteam AchievementsFull controller supportCustom Volume ControlsPlayable without Timed InputStereo SoundSurround Sound3 DLC

9 supported languages: English, Russian, French, German, Spanish - Spain, Simplified Chinese, Portuguese - Brazil, Japanese, Korean

Census log

Computed from census-recorded observations only — dates are observation dates.

Players also track

BrawloutPikunikuCooking SimulatorRICODream AloneRADDude Simulator 2Apsulov: End of Gods

Similarity via IGDB.

Official site ↗Discord ↗